en جراحی سرطان Surgical oncology نامه به سر دبیر Letter to Editor <p data-end="963" data-start="86" style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:2;">Hepatocellular carcinoma (HCC), the sixth most common cancer and the third leading cause of cancer deaths worldwide, remains a major health concern. Recurrence occurs in up to 70% of cases within five years post-surgery, underscoring the need for better management strategies. Despite advancements in surveillance, detection, and treatment, such as surgical resection, liver transplant, and local ablative therapy, the prognosis remains poor. This persistent risk underscores the need for improved strategies in surgical patient selection, prognostic stratification, and postoperative management. Alpha-fetoprotein (AFP), long regarded as a diagnostic and surveillance biomarker, has gained renewed attention for its dynamic role in predicting outcomes after surgical intervention. Recent studies, including one performed by Song et al., highlight the importance of recurrent AFP (r-AFP) kinetics in patients undergoing repeat hepatectomy. Their results show a substantial correlation between r-AFP positivity and a worse recurrence-death survival rate, indicating that AFP dynamics offer useful information beyond static baseline measures.</span></span></span></p> Alpha Fetoprotein, Recurrence, Therapeutics 1 2 http://jsurgery.bums.ac.ir/browse.php?a_code=A-10-505-1&slc_lang=en&sid=1 Haider Imran haiderimran15@gmail.com 100319475328460012107 0009-0005-7609-6672 No Department of Medicine, Foundation University Medical College, Islamabad, Pakistan Zahra Ali Haque zahraalihaque5@gmail.com 100319475328460012108 0009-0002-3146-8282 Yes Department of Medicine, Islamic International Medical College, Rawalpindi, Pakistan Amal Khan khanamal841@gmail.com 100319475328460012109 0009-0008-7501-3291 No Department of Medicine, Foundation University Medical College, Islamabad, Pakistan