Nasogastric tube (NG) insertion is a usual technique in any neonatal intensive care unit. This procedure is undertaken for the children who are in need of invasive care. Sometimes, the insertion of nasogastric tube in infants with esophagus friable anatomy tissues may have some dangerous side effect, but such problems are not very common. Esophageal perforation is a rare but known complication of these procedures. In this study, we present the case of an infant with esophageal perforation. This infant was diagnosed incidentally on X-rays. This problem is usually associated with critically ill patients in the NICU.