Pterygium is characterized by an elastic degeneration of the conjunctiva that extends across the limbos and invades the cornea. The recurrence rate is varied from 25-80% after primary closure to 6% with free conjunctival and Iimbal grafts. Several adjunctive therapies have been investigated for recurrent pte¬rygium. This article presents a 52-year-old athletic man who was seen for evaluation of a recurrent lesion in his right eye and treated with topical administration of IFN-α-2b (Intron A, Schering Plough, Kenilworth, NJ), 1 million units/mL 4 times a day as eye drops.