en قلب و عروق Cardialogy پژوهشي Research <div style="text-align: justify;"><strong>Introduction: </strong>Although various factors have been recognized influencing the short-term and long-term survival of patients suffering from a heart attack, there are some other factors that have not been determined as prognostic factors affecting the survival of patients. One of these factors is the history of opioid use among patients. This study was conducted to investigate the relationship between the survival of patients suffering from acute myocardial infarction (AMI) and the use of opioids.</div> <div style="text-align: justify;"><strong>Methods: </strong>This prospective cohort study was carried out on 222 patients suffering from AMI admitted to two teaching hospitals. The patients who passed away in the emergency department were excluded from this study. All patients were divided into two consumers or non-consumers groups according to the past and present use of opioids. The patients&#39; status was investigated within 3 months of hospitalization while their clinical symptoms were recorded. The collected data were analyzed in SPSS software (Version 18) using the Mann&ndash;Whitney U test and independent t-test. A p-value of < 0.05 was considered significant.</div> <div style="text-align: justify;"><strong>Results: </strong>The mean age scores of subjects in the case and control groups were 61.3&plusmn;13.2 and 61.5&plusmn;12.6, respectively. Both groups had the same history of diabetes, hyperlipidemia, hypertension, and ischemic heart disease. Based on the results, although the mean score of survival of patients in the opioid user group was slightly higher than that in the control group within 1, 2, and 3 months after the hospitalization, this difference was not significant (P>0.05).</div> <div style="text-align: justify;"><strong>Conclusions: </strong>Opioid use has not any significant effect on the pain severity or mortality (survival) of patients after heart attack during 1, 2, or 3 months.</div> Ischemic Heart Disease, Opioid, Survival 98 102 http://jsurgery.bums.ac.ir/browse.php?a_code=A-10-114-5&slc_lang=en&sid=1 Hossein Saidi drhsaidi@yahoo.com 10031947532846008019 10031947532846008019 No Emergency Medicine Management Research Center, Iran University of Medical Sciences, Tehran, Iran Kaveh Naderi drkavehnaderi@gmail.com 10031947532846008020 10031947532846008020 No Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Farahnaz Janmohammadi janmohamadifarahnaz48@gmail.com 10031947532846008021 10031947532846008021 No Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Leili Namdari mah_re@yahoo.com 10031947532846008022 10031947532846008022 No Emergency Medicine Management Research Center, Iran University of Medical Sciences, Tehran, Iran Amir Noyani amir_noiany@yahoo.com 10031947532846008023 10031947532846008023 No Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran Mahdi Rezai rezaei.m@iums.ac.ir 10031947532846008024 10031947532846008024 No Emergency Medicine Management Research Center, Iran University of Medical Sciences, Tehran, Iran Manizhe Nasirizade m.nassirizadeh@yahoo.com 10031947532846008025 10031947532846008025 Yes Faculty of Nursing and Midwifery College, Birjand University of Medical Sciences, Birjand, Iran