en Comparison of Epidural versus Entonox for Labor Analgesia in Nulliparous Women عمومى General پژوهشي Research <p><font face="Times New Roman" size="3">&nbsp;</font><b><span 8pt="" style="font-family: " traditional="">Introduction:</span></b><span 8pt="" style="font-family: " traditional=""> The aim of this study is to compare the efficacy of epidural versus entonox methods for labor analgesia in nulliparous women.</span><span 9pt="" style="font-family: " tahoma=""></span><font face="Times New Roman" size="3">&nbsp;</font></p> <p><b><span 8pt="" style="font-family: " traditional="">Methods:</span></b><span 9pt="" style="font-family: " traditional=""> This randomized controlled trial was performed on 84 nulliparous women with - pregnancy admitted to Imam Reza Hospital in 10 May 2010- 10 May 2011.</span><font face="Times New Roman" size="3">&nbsp;</font></p> <p><span 9pt="" style="font-family: " traditional="">They were randomly divided into two groups 42 women inhaled entonox in active phase at the beginning of each contraction, and for 42 cases, epidural catheter was inserted and analgesic substance was injected and it was increased adjusted with contraction progressing by bupivacaine combined with fentanyl. The rate of pain was measured with pain scores (minimum pain 0 and maximum pain 10). </span></p> <p><font face="Times New Roman" size="3">&nbsp;</font><b><span 8pt="" style="font-family: " traditional="">Results:</span></b><span 9pt="" style="font-family: " traditional=""> In epidural analgesia, pain score was lower in all stages of labor than entonox analgesia 42% of cases had no pain, while as in entonox group, pain has been decreased 4 scores in 7% of cases and there was no complete analgesia. Duration of different stages of labor was not statistically different between two groups (P=0.89). Cesarean rate was similar in two groups. First and five minute Apgar were not statistically different between two groups (P=0.87, P=0.75, respectively).<font face="Calibri"><span style="mso-spacerun: yes">&nbsp;</span></font></span></p> <p><b><span 8pt="" style="font-family: " traditional="">Conclusions: </span></b><span 9pt="" style="font-family: " traditional="">Epidural analgesia with more relief in labor pain is the desired method. This method doesn&rsquo;t cause more cesarean rate or prolonged labor duration. Although Entonox decreases labor pain in first stage, but doesn&rsquo;t affect on second stage and fetus Apgar. </span><font face="Times New Roman" size="3">&nbsp;</font></p> Entonox, Epidural analgesia, Labor pain 1 5 http://jsurgery.bums.ac.ir/browse.php?a_code=A-10-27-1&slc_lang=en&sid=1 Nayereh Khadem Nayereh Khadem 10031947532846003179 10031947532846003179 No Department of Obstetrics and Gynecology, Women’s Health Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Nahid Zirak Nahid Zirak ZirakN@mums.ac.ir 10031947532846003180 10031947532846003180 Yes Department of Anesthesiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Ghasem Soltani Ghasem Soltani 10031947532846003181 10031947532846003181 No Cardiac Anesthesia Research Center, Anesthesia Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Nahid Sahebdelfar Nahid Sahebdelfar 10031947532846003182 10031947532846003182 No Department of Obstetrics and Gynecology, Mashhad, Iran Alireza Sepehri Shamloo Alireza Sepehri Shamloo 10031947532846003183 10031947532846003183 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Saeed Ebrahimzadeh Saeed Ebrahimzadeh 10031947532846003184 10031947532846003184 No Health Faculty, Mashhad University of Medical Sciences, Mashhad, Iran