en جراحی عمومی General Surgery متاآنالیز Meta-analysis <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Tahoma;"><b><span lang="EN-GB">Introduction:</span></b> There are numerous questions surrounding the use, duration of administration, and dosage of clotting factor concentrates (CFC). This issue has been so far very controversial and challenging. Given the critical oitre1importance of the subject, the present study aimed to assess the outcomes of perioperative hemostatic management in hemophilia patients without inhibitors undergoing invasive or surgical procedures.<br> <b><span lang="EN-GB">Methods:</span></b> A<span style="color:black">ll articles published in international databases, such as PubMed, Scopus, Science Direct, and Embase, until May 2022 were included. Data analysis was performed using STATA software (version 16).</span><br> <b><span lang="EN-GB">Results:</span></b> <span style="color:black">The search in databases yielded 1,218 articles and the full text of 192 articles was reviewed. Finally, nine articles that met the inclusion criteria entered the analysis. Mean differences of bleeding rate between high-dose prophylaxis and episodic groups was -53.40 (MD; 95 CI (-53.72, -53.08); P=0.01). The mean differences of joint bleeding rate between intermediate dose prophylaxis and episodic groups was -12.79 (MD; 95 CI (-12.85, -12.74); P=0.01). </span><br> <b><span lang="EN-GB">Conclusion:</span></b> <span style="color:black">Based on the present meta-analysis, it was revealed that in patients with hemophilia A, the use of prophylaxis has better results in terms of annualized bleeding rate&nbsp;and annualized joint bleeding rate&nbsp;than episodic treatment.</span></span></span></div> Bleeding, Disease management, Hemophilia, Hemostatics 129 136 http://jsurgery.bums.ac.ir/browse.php?a_code=A-10-227-3&slc_lang=en&sid=1 Mehran Ebrahimi Shah-abadi historyfive@yahoo.com 100319475328460010680 100319475328460010680 No Department of Surgery, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran Mahdi Heydari Mahdiheydari438@yahoo.com 100319475328460010681 0009-0004-8731-2548 No Department of Anatomical Sciences, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran Mohsen Najmaddini Dr.mohsen_najmaddini@yahoo.com 100319475328460010682 100319475328460010682 Yes Assistant fellowship of Surgical Oncology, Mashhad University of Medical Sciences, Mashhad, Iran Ehsan Soltani soltanie@mums.ac.ir 100319475328460010683 100319475328460010683 No Associate Professor of Surgical Oncology , Mashhad University of Medical Sciences, Mashhad, Iran