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Jalal Ahmadi, Fatemeh Hoseinzadeh-Chahkandak, Maryam Yousefi-Roobiyat, Ali Mohammad Pourbagher-Shahri, Shahriar Irankhah, Ali Rajabpour-Sanati,
Volume 8, Issue 1 (4-2020)

  • Introduction: The ever-increasing and common occurrence of head traumas highlight the importance of adopting therapeutic measures for the reduction of the associated morbidity and mortality. Citicoline, as a safe medicine with positive effects on improving traumatic injuries, has been proven to be useful in various studies. However, there are still no data on the specific standard method and dosage of citicoline for the treatment of patients with traumatic head injuries. Regarding this, the present study was performed to determine the effective therapeutic dosage of citicoline and its impact on patients with traumatic head injuries.
  • Methods: This double-blind clinical trial was performed on 30 patients with traumatic concussion (a Glasgow coma scale [GCS] of ≤8) admitted to the intensive care unit and neurosurgery department. The patients were randomly divided into three groups of A (control), B (citicoline with a dosage of 0.5 g/twice a day), and C (citicoline with a dosage of 1.5 g/twice a day). The GCS, degree of muscle strength, Glasgow outcome score (GOS), contusion volume, and cerebral edema (based on brain CT scans) were calculated at specific times and intervals. In addition, the patients' dependency on a ventilator and their length of ICU stay were registered.
  • Results: Mean GCS on the first day of stay, GCS changes on the third and fourth days of stay, first and seventh days of stay, seventh and fourteenth days of stay, and first and fourteenth days of stay in the three study groups showed the significant statistical difference (P<0.05). Significant statistical differences were seen between the GOS of the 30th day of stay in the three study groups (P<0.05). The contusion volume difference was only significant between the first and seventh days of stay in groups A and C (P<0.05). No significant difference was observed in the mean length of stay in ICU and duration of dependency on a ventilator in the three study groups (P<0.05). The mean degree of muscle strength was only significantly different on the first day of stay between groups B and C (P=0.008).
  • Conclusions: In contrary to similar studies, the results of the current study revealed that citicoline had no positive effect on patient healing. This result may be due to the small sample size and the inconsistent first-day GCSs of the patients in all three groups. Therefore, given the confirmation of the effectiveness of citicoline even at higher dosages in other studies in future studies, it is recommended to use populations with a larger number of patients.

Narjes Akbari, Marzieh Mohamadimoghadam, Amir Mohammad Chaji,
Volume 10, Issue 4 (12-2022)

  • Introduction: Dental surgeries are always associated with pain and swelling for several consecutive days. Recent articles have shown conflicting results in the use of new techniques such as low-power lasers to treat postoperative pain and swelling. This study aimed to evaluate the reduction of pain, swelling, and trismus after surgery of the third molar-impacted tooth after the use of a low-power laser.
  • Method: This study was a randomized, single-blind, split-mouth clinical trial involving patients who were referred to the special clinic of Birjand Dental School from December 2021 to June 2021 and required bilateral removal of the occluded third molars. Immediately after surgery, the patient was given a radiation laser with a wavelength of 780 nm and a power of 70 MW for 30 seconds at a dose or power density of 52.5 j/cm2. The extent of swelling and trismus was assessed by measuring the dimensions of the face and the amount of mouth opening as well as the amount of pain on the second and seventh days after surgery. Statistical analysis was performed using the Wilcoxon and Mann–Whitney U test by SPSS (Version 21) at the significant level of (5 %).
  • Results: The intensity of pain and swelling decreased significantly over time and the amount of trismus increased significantly during the seventh day compared to the second day (p.value<0.05). The amount of pain on the 7th day after surgery in the group without laser was 1.98±0.26 and the amount of pain in the group with laser was 0.85 ± 0.92 which was not statistically significant between the two groups (value>0.05). The amount of trismus on 7-day was 38.79 ±9.94 and on the side, with laser, it was no significant difference. The distance between the tragus and the corner of the lip on day 7 after surgery was 110.03 ± 5.77 mm and in the laser group was 109.66 ±5.67 mm, no significant difference was observed between the two groups. The distance between the gonium and the outer corner on day 7 after surgery was 98.84 ±7.24 mm in the laser group and 98.21± 6.93 mm in the non-laser group and no significant difference was observed.
  • Conclusion: The use of low-power laser reduced the pain, reduce postoperative swelling, and trismus caused by surgery but this reduction was not significant. Therefore, it is suggested that the study method should be changed and the sample size must be increased in further studies.

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