Journal of Surgery and Trauma
نشریه جراحی و تروما
J Surg Trauma
Medical Sciences
http://jsurgery.bums.ac.ir
1
admin
2345-4873
2345-4873
en
jalali
1397
2
1
gregorian
2018
5
1
6
2
online
1
fulltext
en
Adjuvant therapy versus surgery in controlling seizure in patients with low-grade glioma tumor
جراحی اعصاب
Neurosurgery
پژوهشي
Research
<strong>Introduction:</strong> Since surgical treatment for tumorous lesions does not always lead to complete patient recovery, it is possible for the attacks to continue. To help plan for the patients' health, this study aimed to compare the therapeutic effects of adjuvant therapy and surgery in controlling seizure of low-grade glioma (LGG) patients in Firoozgar Hospital in 2013-2014.<br>
<strong>Methods:</strong> In this analytical cross-sectional study, 114 patients with LGG (grade 2) tumors admitted in Firoozgar Hospital during 2013-2014 were divided into two groups of adjuvant therapy and surgical treatment. All of these patients were followed by telephone and were asked about the incidence, frequency, and intensity of seizure attacks up to one year after surgery. The age and sex of the patients, along with the drug used after surgery, were also recorded on a checklist. Electroencephalography (EEG) was performed on all the patients under the supervision of a neurologist. Patient information was entered into the SPSS V.16 and analyzed. Chi-2 test was used to analyze and compare the qualitative variables, and T-test was employed to compare quantitative variables between the two groups. Alpha values below 0.05 were considered significant.<br>
<strong>Results:</strong> In the present study, the incidence of seizure after surgery and adjuvant therapy were 16 (1.28%) and 20 (35.1%), respectively. The severity of seizure before and after treatment was not significantly different between the two groups. However, in both groups, the severity and frequency of seizure decreased significantly after treatment, although there was no significant difference between the two groups before and after treatment. In the surgery group, 17 patients (29.82%) and in the adjuvant therapy group, 19 patients (33.33%) had an unusual EEG. There was a significant correlation between the post-treatment seizure and abnormal EEG (p <0.001).<br>
<strong>Conclusions:</strong> Based on the results of this study, it can be concluded that the incidence, severity, and frequency of seizure in patients with LGG were decreased after surgical treatment or adjunct therapy, but there is no significant difference between the two methods.
Brain Neoplasm, Seizure, Adjuvant therapy, Glioma , Surgery
50
54
http://jsurgery.bums.ac.ir/browse.php?a_code=A-10-172-1&slc_lang=en&sid=1
Mehdi
Nikoobakht
mnikobakht@gmail.com
1111
10031947532846006535
Yes
Assistant Professor of Neurosurgery , Department of Neurosurgery, Firoozgar Clinical Research and Development Center(FCRDC) Iran University of Medical ScienceS(IUMS)Tehran, Iran
Maziar
Azar
maziarazar@yahoo.com
2222
10031947532846006536
No
Associate Professor, Neurosurgery ward of Rasool-e-Akram Hospital Complex, Department of Neurosurgery, Iran University of Medical Sciences, Tehran
Amir
Pakpour Hajiagha
Pakpour_Amir@yahoo.com
333
10031947532846006537
No
Associate Professor of health psychology, Department of Public Health, Faculty of Health, Qazvin University of Medical Sciences, Qazvin, Iran
Seyedeh Fahimeh
Shojaei
shojaee.fahimeh@yahoo.com
10031947532846006538
10031947532846006538
No
MSc, Clinical Psychologist, Firoozgar Clinical Research and Development Center (FCRDC), Iran University of Medical Sciences (IUMS), Tehran, Iran
Yasaman
Khalili Baseri
yasaman.khalilibaseri@gmail.com
4444
10031947532846006539
No
Medical Student, Young Researchers and Elites Club, Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran.