en جراحی_عفونی Surgery_Infectious گزارش مورد Case Report <ul> <li style="text-align: justify;">Nicolau syndrome (NS) is a rare aseptic cutaneous adverse reaction and necrosis caused by intra-muscular, subcutaneous,intravenous, or intra-articular injection of various drugs. We report a case of this syndrome. A 20-year-old male who developedintense pressure pain, the local sensation of heat, and reddish discoloration of the skin after receiving an intramuscular injection ofdiclofenac for renal colic. The complaints started two days after the injection. The patient was managed at peripheral health care center as a case of post-injection site abscess. However, the patient developed gluteal necrosis and was referred to our tertiary care center for further management. The patient was treated with antibiotics, and aggressive multiple debridements, and healed with secondary intention with an ugly scar. The observed syndrome was due to the injection of the drug into subcutaneous tissue instead of proper muscular planes. Medical and paramedical personnel must be properly educated and sensitized to such a complication that can occur during drug administration. They should follow the standard and appropriate injection techniques and take all necessary precautions to avoid this severe complication, which increases the patient&#39;s morbidity. Proper teachings of injection techniques to junior medical and paramedical staff should be exercised at the apex and peripheral centers for the prevention of this syndrome.</li> </ul> Embolia Cutis Medicamentosa, Nicolau Syndrome, Diclofenac, Renal Colic 35 38 http://jsurgery.bums.ac.ir/browse.php?a_code=A-10-290-3&slc_lang=en&sid=1 Yaqoob Hassan dryaqoobwani@gmail.com 10031947532846008506 10031947532846008506 Yes MBBS,MS SKIMS Medical College, Srinagar, Kashmir Humayoon Rasool drhumayoon.hrr@gmail.com 10031947532846008507 10031947532846008507 No MBBS,MS SKIMS Medical College, Srinagar, Kashmir Ajaz Ahmad Rather drajazrather@gmail.com 10031947532846008508 10031947532846008508 No MBBS,MS,FRCS,FICS SKIMS Medical College, Srinagar, Kashmir Mehvish Hilal Wani mehvishwani19@gmail.com 10031947532846008509 10031947532846008509 No MBBS, SKIMS Medical College, Srinagar, Kashmir