Article in Press
Back to the articles list |
Back to browse issues page
Assistant fellowship of Surgical Oncology, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract: (18 Views)
Introduction: There are numerous questions surrounding the use, duration of administration, and dosage of clotting factor concentrates (CFC). This issue has been so far very controversial and challenging. Given the critical oitre1importance of the subject, the present study aimed to assess the outcomes of perioperative hemostatic management in hemophilia patients without inhibitors undergoing invasive or surgical procedures.
Methods: All articles published in international databases, such as PubMed, Scopus, Science Direct, and Embase, until May 2022 were included. Data analysis was performed using STATA software (version 16).
Results: The search in databases yielded 1,218 articles and the full text of 192 articles was reviewed. Finally, nine articles that met the inclusion criteria entered the analysis. Mean differences of bleeding rate between high-dose prophylaxis and episodic groups was -53.40 (MD; 95 CI (-53.72, -53.08); P=0.01). The mean differences of joint bleeding rate between intermediate dose prophylaxis and episodic groups was -12.79 (MD; 95 CI (-12.85, -12.74); P=0.01).
Conclusion: Based on the present meta-analysis, it was revealed that in patients with hemophilia A, the use of prophylaxis has better results in terms of annualized bleeding rate and annualized joint bleeding rate than episodic treatment.
Methods: All articles published in international databases, such as PubMed, Scopus, Science Direct, and Embase, until May 2022 were included. Data analysis was performed using STATA software (version 16).
Results: The search in databases yielded 1,218 articles and the full text of 192 articles was reviewed. Finally, nine articles that met the inclusion criteria entered the analysis. Mean differences of bleeding rate between high-dose prophylaxis and episodic groups was -53.40 (MD; 95 CI (-53.72, -53.08); P=0.01). The mean differences of joint bleeding rate between intermediate dose prophylaxis and episodic groups was -12.79 (MD; 95 CI (-12.85, -12.74); P=0.01).
Conclusion: Based on the present meta-analysis, it was revealed that in patients with hemophilia A, the use of prophylaxis has better results in terms of annualized bleeding rate and annualized joint bleeding rate than episodic treatment.
Type of Study: Meta-analysis |
Subject:
General Surgery
Received: 2023/06/23 | Accepted: 2024/12/15 | ePublished ahead of print: 2025/02/22
Received: 2023/06/23 | Accepted: 2024/12/15 | ePublished ahead of print: 2025/02/22
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Attribution-NoneCommercial CC BY-NC
