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:: Volume 3, Issue 3 And 4 (10-2015) ::
Journal of Surgery and Trauma 2015, 3(3 And 4): 57-59 Back to browse issues page
Intestinal perforation in a patient with paroxysmal nocturnal hemoglobinuria
Reza Kayat , Elahe Bijari
Student Research Committee, Faculty of Medicine, Birjand University of Medical sciences Birjand, Iran Student Research Committee, Faculty of Medicine, Birjand University of Medical sciences Birjand, Iran
Abstract:   (569 Views)

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.Acute abdominal pain is one of the PNH clinical manifestations due to venous thrombosis of intra-abdominal sites including hepatic, portal, mesenteric, and splenic veins.Eculizumaband allogeneic bone marrow transplantation (BMT) arethe only widely effective therapies for these patients.

We report a case of PNH disorder which presented with abdominal pain and mild tenderness. Abdominal X ray and sonography revealed intra-peritonealfree fluid and air. At laparotomy, an ischemic segment of jejunum with stricture and perforationwith mesenteric venous thrombosis were found. The patient also had a history of hepatic vein thrombosis two years before.

Keywords: Paroxysmal Nocturnal Hemoglobinuria, Intestinal Perforation, Thrombosis, Abdominal Pain
Full-Text [PDF 619 kb]   (362 Downloads)    
Type of Study: case report |
Received: 2016/10/3 | Accepted: 2016/11/26 | Published: 2016/12/25
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Kayat R, Bijari E. Intestinal perforation in a patient with paroxysmal nocturnal hemoglobinuria. Journal of Surgery and Trauma . 2015; 3 (3 and 4) :57-59
URL: http://jsurgery.bums.ac.ir/article-1-72-en.html
Volume 3, Issue 3 And 4 (10-2015) Back to browse issues page
نشریه جراحی و تروما Journal of Surgery and Trauma
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