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:: Volume 3, Number 3 and 4 (10-2015) ::
Journal of Surgery and Trauma 2015, 3(3 and 4): 57-59 Back to browse issues page
Intestinal perforation in a patient with paroxysmal nocturnal hemoglobinuria
Reza Kayat, Elahe Bijari
Student Research Committee, Faculty of Medicine, Birjand University of Medical sciences Birjand, Iran Student Research Committee, Faculty of Medicine, Birjand University of Medical sciences Birjand, Iran
Abstract:   (443 Views)

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.Acute abdominal pain is one of the PNH clinical manifestations due to venous thrombosis of intra-abdominal sites including hepatic, portal, mesenteric, and splenic veins.Eculizumaband allogeneic bone marrow transplantation (BMT) arethe only widely effective therapies for these patients.

We report a case of PNH disorder which presented with abdominal pain and mild tenderness. Abdominal X ray and sonography revealed intra-peritonealfree fluid and air. At laparotomy, an ischemic segment of jejunum with stricture and perforationwith mesenteric venous thrombosis were found. The patient also had a history of hepatic vein thrombosis two years before.

Keywords: Paroxysmal Nocturnal Hemoglobinuria, Intestinal Perforation, Thrombosis, Abdominal Pain
Full-Text [PDF 619 kb]   (312 Downloads)    
Type of Study: case report |
Received: 2016/10/3 | Accepted: 2016/11/26 | Published: 2016/12/25
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Kayat R, Bijari E. Intestinal perforation in a patient with paroxysmal nocturnal hemoglobinuria. Journal of Surgery and Trauma . 2015; 3 (3 and 4) :57-59
URL: http://jsurgery.bums.ac.ir/article-1-72-en.html
Volume 3, Number 3 and 4 (10-2015) Back to browse issues page
نشریه جراحی و تروما Journal of Surgery and Trauma
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